Sleep disorders and depression in patients with Parkinson's disease
Identifieur interne : 000C57 ( Main/Corpus ); précédent : 000C56; suivant : 000C58Sleep disorders and depression in patients with Parkinson's disease
Auteurs : S. Happe ; B. Schrödl ; M. Faltl ; C. Müller ; E. Auff ; J. ZeitlhoferSource :
- Acta Neurologica Scandinavica [ 0001-6314 ] ; 2001-11.
English descriptors
- KwdEn :
Abstract
Objectives– Sleep disorders and depression are frequent in patients with Parkinson's disease (PD). However, the exact prevalence and the causality are still unknown. Patients and methods– We interviewed 56 consecutive PD patients and 59 age‐matched healthy controls concerning sleep disorders and depression. Sleep Disorders Questionnaire (SDQ) and Zung Depression Scale (ZDS) were used as standardized valid and reliable psychometric tests. Results– Patients with PD had significantly higher values in the clinical‐diagnostic scale narcolepsy (P=0.01), correlating with the l‐dopa dose (P=0.007). Concerning sleep apnea (P=0.49), psychiatric sleep disorder (P=1.00) and periodic limb movement disorder (P=0.12), no significant difference could be identified. PD patients showed significantly higher depression scores than healthy control subjects (P=0.01), increasing with the duration of PD (P=0.04). Conclusion– The significant higher narcolepsy score in PD patients must be seen due to dopaminergic medication and PD‐specific neurodegeneration and immobility rather than due to narcolepsy. This leads to the conclusion that extreme caution is advised when carrying out the SDQ and interpreting the results in various persons and patient groups with motor problems. The strong association of depression, disease severity and sleep disorders in PD patients underlines the importance of identifying and treating both conditions in these patients.
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DOI: 10.1034/j.1600-0404.2001.00024.x
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sleep disorders and depression in patients with Parkinson's disease</title><author><name sortKey="Happe, S" sort="Happe, S" uniqKey="Happe S" first="S." last="Happe">S. Happe</name><affiliation><mods:affiliation>Department of Neurology, University of Vienna, Austria,</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, University of Müster, Germany,</mods:affiliation></affiliation></author><author><name sortKey="Schrodl, B" sort="Schrodl, B" uniqKey="Schrodl B" first="B." last="Schrödl">B. Schrödl</name><affiliation><mods:affiliation>Department of Neurology, University of Vienna, Austria,</mods:affiliation></affiliation></author><author><name sortKey="Faltl, M" sort="Faltl, M" uniqKey="Faltl M" first="M." last="Faltl">M. Faltl</name><affiliation><mods:affiliation>Department of Neurological Rehabilitation, University of Vienna, Austria</mods:affiliation></affiliation></author><author><name sortKey="Muller, C" sort="Muller, C" uniqKey="Muller C" first="C." last="Müller">C. Müller</name><affiliation><mods:affiliation>Department of Neurological Rehabilitation, University of Vienna, Austria</mods:affiliation></affiliation></author><author><name sortKey="Auff, E" sort="Auff, E" uniqKey="Auff E" first="E." last="Auff">E. Auff</name><affiliation><mods:affiliation>Department of Neurological Rehabilitation, University of Vienna, Austria</mods:affiliation></affiliation></author><author><name sortKey="Zeitlhofer, J" sort="Zeitlhofer, J" uniqKey="Zeitlhofer J" first="J." last="Zeitlhofer">J. Zeitlhofer</name><affiliation><mods:affiliation>Department of Neurology, University of Vienna, Austria,</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8E634EA3AD763BFABCC9082980339A44820FE673</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1034/j.1600-0404.2001.00024.x</idno><idno type="url">https://api.istex.fr/document/8E634EA3AD763BFABCC9082980339A44820FE673/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000C57</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Sleep disorders and depression in patients with Parkinson's disease</title><author><name sortKey="Happe, S" sort="Happe, S" uniqKey="Happe S" first="S." last="Happe">S. Happe</name><affiliation><mods:affiliation>Department of Neurology, University of Vienna, Austria,</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, University of Müster, Germany,</mods:affiliation></affiliation></author><author><name sortKey="Schrodl, B" sort="Schrodl, B" uniqKey="Schrodl B" first="B." last="Schrödl">B. Schrödl</name><affiliation><mods:affiliation>Department of Neurology, University of Vienna, Austria,</mods:affiliation></affiliation></author><author><name sortKey="Faltl, M" sort="Faltl, M" uniqKey="Faltl M" first="M." last="Faltl">M. Faltl</name><affiliation><mods:affiliation>Department of Neurological Rehabilitation, University of Vienna, Austria</mods:affiliation></affiliation></author><author><name sortKey="Muller, C" sort="Muller, C" uniqKey="Muller C" first="C." last="Müller">C. Müller</name><affiliation><mods:affiliation>Department of Neurological Rehabilitation, University of Vienna, Austria</mods:affiliation></affiliation></author><author><name sortKey="Auff, E" sort="Auff, E" uniqKey="Auff E" first="E." last="Auff">E. Auff</name><affiliation><mods:affiliation>Department of Neurological Rehabilitation, University of Vienna, Austria</mods:affiliation></affiliation></author><author><name sortKey="Zeitlhofer, J" sort="Zeitlhofer, J" uniqKey="Zeitlhofer J" first="J." last="Zeitlhofer">J. Zeitlhofer</name><affiliation><mods:affiliation>Department of Neurology, University of Vienna, Austria,</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Neurologica Scandinavica</title><idno type="ISSN">0001-6314</idno><idno type="eISSN">1600-0404</idno><imprint><publisher>Munksgaard International Publishers</publisher><pubPlace>Copenhagen</pubPlace><date type="published" when="2001-11">2001-11</date><biblScope unit="volume">104</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="275">275</biblScope><biblScope unit="page" to="280">280</biblScope></imprint><idno type="ISSN">0001-6314</idno></series><idno type="istex">8E634EA3AD763BFABCC9082980339A44820FE673</idno><idno type="DOI">10.1034/j.1600-0404.2001.00024.x</idno><idno type="ArticleID">ANE024</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-6314</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>Sleep Disorders Questionnaire (SDQ)</term><term>Zung Depression Scale (ZDS)</term><term>depression</term><term>sleep disorders</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objectives– Sleep disorders and depression are frequent in patients with Parkinson's disease (PD). However, the exact prevalence and the causality are still unknown. Patients and methods– We interviewed 56 consecutive PD patients and 59 age‐matched healthy controls concerning sleep disorders and depression. Sleep Disorders Questionnaire (SDQ) and Zung Depression Scale (ZDS) were used as standardized valid and reliable psychometric tests. Results– Patients with PD had significantly higher values in the clinical‐diagnostic scale narcolepsy (P=0.01), correlating with the l‐dopa dose (P=0.007). Concerning sleep apnea (P=0.49), psychiatric sleep disorder (P=1.00) and periodic limb movement disorder (P=0.12), no significant difference could be identified. PD patients showed significantly higher depression scores than healthy control subjects (P=0.01), increasing with the duration of PD (P=0.04). Conclusion– The significant higher narcolepsy score in PD patients must be seen due to dopaminergic medication and PD‐specific neurodegeneration and immobility rather than due to narcolepsy. This leads to the conclusion that extreme caution is advised when carrying out the SDQ and interpreting the results in various persons and patient groups with motor problems. The strong association of depression, disease severity and sleep disorders in PD patients underlines the importance of identifying and treating both conditions in these patients.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>S. Happe</name><affiliations><json:string>Department of Neurology, University of Vienna, Austria,</json:string><json:string>Department of Neurology, University of Müster, Germany,</json:string></affiliations></json:item><json:item><name>B. Schrödl</name><affiliations><json:string>Department of Neurology, University of Vienna, Austria,</json:string></affiliations></json:item><json:item><name>M. Faltl</name><affiliations><json:string>Department of Neurological Rehabilitation, University of Vienna, Austria</json:string></affiliations></json:item><json:item><name>C. Müller</name><affiliations><json:string>Department of Neurological Rehabilitation, University of Vienna, Austria</json:string></affiliations></json:item><json:item><name>E. Auff</name><affiliations><json:string>Department of Neurological Rehabilitation, University of Vienna, Austria</json:string></affiliations></json:item><json:item><name>J. Zeitlhofer</name><affiliations><json:string>Department of Neurology, University of Vienna, Austria,</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>sleep disorders</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>depression</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Sleep Disorders Questionnaire (SDQ)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Zung Depression Scale (ZDS)</value></json:item></subject><articleId><json:string>ANE024</json:string></articleId><language><json:string>eng</json:string></language><abstract>Objectives– Sleep disorders and depression are frequent in patients with Parkinson's disease (PD). However, the exact prevalence and the causality are still unknown. Patients and methods– We interviewed 56 consecutive PD patients and 59 age‐matched healthy controls concerning sleep disorders and depression. Sleep Disorders Questionnaire (SDQ) and Zung Depression Scale (ZDS) were used as standardized valid and reliable psychometric tests. Results– Patients with PD had significantly higher values in the clinical‐diagnostic scale narcolepsy (P=0.01), correlating with the l‐dopa dose (P=0.007). Concerning sleep apnea (P=0.49), psychiatric sleep disorder (P=1.00) and periodic limb movement disorder (P=0.12), no significant difference could be identified. PD patients showed significantly higher depression scores than healthy control subjects (P=0.01), increasing with the duration of PD (P=0.04). Conclusion– The significant higher narcolepsy score in PD patients must be seen due to dopaminergic medication and PD‐specific neurodegeneration and immobility rather than due to narcolepsy. This leads to the conclusion that extreme caution is advised when carrying out the SDQ and interpreting the results in various persons and patient groups with motor problems. The strong association of depression, disease severity and sleep disorders in PD patients underlines the importance of identifying and treating both conditions in these patients.</abstract><qualityIndicators><score>5.811</score><pdfVersion>1.2</pdfVersion><pdfPageSize>595 x 842 pts (A4)</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1447</abstractCharCount><pdfWordCount>3435</pdfWordCount><pdfCharCount>23347</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>198</abstractWordCount></qualityIndicators><title>Sleep disorders and depression in patients with Parkinson's disease</title><genre><json:string>article</json:string></genre><host><volume>104</volume><publisherId><json:string>ANE</json:string></publisherId><pages><total>6</total><last>280</last><first>275</first></pages><issn><json:string>0001-6314</json:string></issn><issue>5</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1600-0404</json:string></eissn><title>Acta Neurologica Scandinavica</title><doi><json:string>10.1111/(ISSN)1600-0404</json:string></doi></host><publicationDate>2001</publicationDate><copyrightDate>2001</copyrightDate><doi><json:string>10.1034/j.1600-0404.2001.00024.x</json:string></doi><id>8E634EA3AD763BFABCC9082980339A44820FE673</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/8E634EA3AD763BFABCC9082980339A44820FE673/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/8E634EA3AD763BFABCC9082980339A44820FE673/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/8E634EA3AD763BFABCC9082980339A44820FE673/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Sleep disorders and depression in patients with Parkinson's disease</title><title level="a" type="sub" xml:lang="en">Results of a study with the Sleep Disorders Questionnaire (SDQ) and the Zung Depression Scale (ZDS)</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Munksgaard International Publishers</publisher><pubPlace>Copenhagen</pubPlace><availability><p>WILEY</p></availability><date>2001</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Sleep disorders and depression in patients with Parkinson's disease</title><title level="a" type="sub" xml:lang="en">Results of a study with the Sleep Disorders Questionnaire (SDQ) and the Zung Depression Scale (ZDS)</title><author><persName><forename type="first">S.</forename><surname>Happe</surname></persName><affiliation>Department of Neurology, University of Vienna, Austria,</affiliation><affiliation>Department of Neurology, University of Müster, Germany,</affiliation></author><author><persName><forename type="first">B.</forename><surname>Schrödl</surname></persName><affiliation>Department of Neurology, University of Vienna, Austria,</affiliation></author><author><persName><forename type="first">M.</forename><surname>Faltl</surname></persName><affiliation>Department of Neurological Rehabilitation, University of Vienna, Austria</affiliation></author><author><persName><forename type="first">C.</forename><surname>Müller</surname></persName><affiliation>Department of Neurological Rehabilitation, University of Vienna, Austria</affiliation></author><author><persName><forename type="first">E.</forename><surname>Auff</surname></persName><affiliation>Department of Neurological Rehabilitation, University of Vienna, Austria</affiliation></author><author><persName><forename type="first">J.</forename><surname>Zeitlhofer</surname></persName><affiliation>Department of Neurology, University of Vienna, Austria,</affiliation></author></analytic><monogr><title level="j">Acta Neurologica Scandinavica</title><idno type="pISSN">0001-6314</idno><idno type="eISSN">1600-0404</idno><idno type="DOI">10.1111/(ISSN)1600-0404</idno><imprint><publisher>Munksgaard International Publishers</publisher><pubPlace>Copenhagen</pubPlace><date type="published" when="2001-11"></date><biblScope unit="volume">104</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="275">275</biblScope><biblScope unit="page" to="280">280</biblScope></imprint></monogr><idno type="istex">8E634EA3AD763BFABCC9082980339A44820FE673</idno><idno type="DOI">10.1034/j.1600-0404.2001.00024.x</idno><idno type="ArticleID">ANE024</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2001</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Objectives– Sleep disorders and depression are frequent in patients with Parkinson's disease (PD). However, the exact prevalence and the causality are still unknown. Patients and methods– We interviewed 56 consecutive PD patients and 59 age‐matched healthy controls concerning sleep disorders and depression. Sleep Disorders Questionnaire (SDQ) and Zung Depression Scale (ZDS) were used as standardized valid and reliable psychometric tests. Results– Patients with PD had significantly higher values in the clinical‐diagnostic scale narcolepsy (P=0.01), correlating with the l‐dopa dose (P=0.007). Concerning sleep apnea (P=0.49), psychiatric sleep disorder (P=1.00) and periodic limb movement disorder (P=0.12), no significant difference could be identified. PD patients showed significantly higher depression scores than healthy control subjects (P=0.01), increasing with the duration of PD (P=0.04). Conclusion– The significant higher narcolepsy score in PD patients must be seen due to dopaminergic medication and PD‐specific neurodegeneration and immobility rather than due to narcolepsy. This leads to the conclusion that extreme caution is advised when carrying out the SDQ and interpreting the results in various persons and patient groups with motor problems. The strong association of depression, disease severity and sleep disorders in PD patients underlines the importance of identifying and treating both conditions in these patients.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>sleep disorders</term></item><item><term>depression</term></item><item><term>Sleep Disorders Questionnaire (SDQ)</term></item><item><term>Zung Depression Scale (ZDS)</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2001-11">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/8E634EA3AD763BFABCC9082980339A44820FE673/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Munksgaard International Publishers</publisherName><publisherLoc>Copenhagen</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0404</doi><issn type="print">0001-6314</issn><issn type="electronic">1600-0404</issn><idGroup><id type="product" value="ANE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ACTA NEUROLOGICA SCANDINAVICA">Acta Neurologica Scandinavica</title></titleGroup></publicationMeta><publicationMeta level="part" position="11005"><doi origin="wiley">10.1111/ane.2001.104.issue-5</doi><numberingGroup><numbering type="journalVolume" number="104">104</numbering><numbering type="journalIssue" number="5">5</numbering></numberingGroup><coverDate startDate="2001-11">November 2001</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0027500" status="forIssue"><doi origin="wiley">10.1034/j.1600-0404.2001.00024.x</doi><idGroup><id type="unit" value="ANE024"></id><id type="supplier" value="ane1o024"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><eventGroup><event type="firstOnline" date="2008-07-07"></event><event type="publishedOnlineFinalForm" date="2008-07-07"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-10"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-15"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="275">275</numbering><numbering type="pageLast" number="280">280</numbering></numberingGroup><correspondenceTo>Josef Zeitlhofer, Department of Neurology/Neurophysiology,
University of Vienna,
Waehringer Guertel 18–20,
1090 Vienna,
Austria
Tel.: +43 1 40400 3100
Fax: +43 1 40400 3141
e‐mail: <email>josef.zeitlhofer@univie.ac.at</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ANE.ANE24.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication June 13, 2001</unparsedEditorialHistory><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="3"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="50"></count><count type="wordTotal" number="0"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="1"></count></countGroup><titleGroup><title type="main">Sleep disorders and depression in patients with Parkinson's disease</title><title type="subtitle">Results of a study with the Sleep Disorders Questionnaire (SDQ) and the Zung Depression Scale (ZDS)</title><title type="shortAuthors">Happe et al.</title><title type="short">Sleep disorders and depression in patients with Parkinson's disease</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1 #a2"><personName><givenNames>S.</givenNames><familyName>Happe</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>B.</givenNames><familyName>Schrödl</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a3"><personName><givenNames>M.</givenNames><familyName>Faltl</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a3"><personName><givenNames>C.</givenNames><familyName>Müller</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a3"><personName><givenNames>E.</givenNames><familyName>Auff</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1"><personName><givenNames>J.</givenNames><familyName>Zeitlhofer</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="AT"><unparsedAffiliation>Department of Neurology, University of Vienna, Austria,</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="DE"><unparsedAffiliation>Department of Neurology, University of Müster, Germany,</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="AT"><unparsedAffiliation>Department of Neurological Rehabilitation, University of Vienna, Austria</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Parkinson's disease</keyword><keyword xml:id="k2">sleep disorders</keyword><keyword xml:id="k3">depression</keyword><keyword xml:id="k4">Sleep Disorders Questionnaire (SDQ)</keyword><keyword xml:id="k5">Zung Depression Scale (ZDS)</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p> <i>Objectives</i>– Sleep disorders and depression are frequent in patients with Parkinson's disease (PD). However, the exact prevalence and the causality are still unknown. <i>Patients and methods</i>– We interviewed 56 consecutive PD patients and 59 age‐matched healthy controls concerning sleep disorders and depression. Sleep Disorders Questionnaire (SDQ) and Zung Depression Scale (ZDS) were used as standardized valid and reliable psychometric tests. <i>Results</i>– Patients with PD had significantly higher values in the clinical‐diagnostic scale narcolepsy (<i>P</i>=0.01), correlating with the <sc>l</sc>‐dopa dose (<i>P</i>=0.007). Concerning sleep apnea (<i>P</i>=0.49), psychiatric sleep disorder (<i>P</i>=1.00) and periodic limb movement disorder (<i>P</i>=0.12), no significant difference could be identified. PD patients showed significantly higher depression scores than healthy control subjects (<i>P</i>=0.01), increasing with the duration of PD (<i>P</i>=0.04). <i>Conclusion</i>– The significant higher narcolepsy score in PD patients must be seen due to dopaminergic medication and PD‐specific neurodegeneration and immobility rather than due to narcolepsy. This leads to the conclusion that extreme caution is advised when carrying out the SDQ and interpreting the results in various persons and patient groups with motor problems. The strong association of depression, disease severity and sleep disorders in PD patients underlines the importance of identifying and treating both conditions in these patients.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Sleep disorders and depression in patients with Parkinson's disease</title><subTitle>Results of a study with the Sleep Disorders Questionnaire (SDQ) and the Zung Depression Scale (ZDS)</subTitle></titleInfo><titleInfo type="abbreviated"><title>Sleep disorders and depression in patients with Parkinson's disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Sleep disorders and depression in patients with Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Happe</namePart><affiliation>Department of Neurology, University of Vienna, Austria,</affiliation><affiliation>Department of Neurology, University of Müster, Germany,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Schrödl</namePart><affiliation>Department of Neurology, University of Vienna, Austria,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Faltl</namePart><affiliation>Department of Neurological Rehabilitation, University of Vienna, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Müller</namePart><affiliation>Department of Neurological Rehabilitation, University of Vienna, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Auff</namePart><affiliation>Department of Neurological Rehabilitation, University of Vienna, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Zeitlhofer</namePart><affiliation>Department of Neurology, University of Vienna, Austria,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Munksgaard International Publishers</publisher><place><placeTerm type="text">Copenhagen</placeTerm></place><dateIssued encoding="w3cdtf">2001-11</dateIssued><edition>Accepted for publication June 13, 2001</edition><copyrightDate encoding="w3cdtf">2001</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">50</extent></physicalDescription><abstract lang="en">Objectives– Sleep disorders and depression are frequent in patients with Parkinson's disease (PD). However, the exact prevalence and the causality are still unknown. Patients and methods– We interviewed 56 consecutive PD patients and 59 age‐matched healthy controls concerning sleep disorders and depression. Sleep Disorders Questionnaire (SDQ) and Zung Depression Scale (ZDS) were used as standardized valid and reliable psychometric tests. Results– Patients with PD had significantly higher values in the clinical‐diagnostic scale narcolepsy (P=0.01), correlating with the l‐dopa dose (P=0.007). Concerning sleep apnea (P=0.49), psychiatric sleep disorder (P=1.00) and periodic limb movement disorder (P=0.12), no significant difference could be identified. PD patients showed significantly higher depression scores than healthy control subjects (P=0.01), increasing with the duration of PD (P=0.04). Conclusion– The significant higher narcolepsy score in PD patients must be seen due to dopaminergic medication and PD‐specific neurodegeneration and immobility rather than due to narcolepsy. This leads to the conclusion that extreme caution is advised when carrying out the SDQ and interpreting the results in various persons and patient groups with motor problems. The strong association of depression, disease severity and sleep disorders in PD patients underlines the importance of identifying and treating both conditions in these patients.</abstract><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>sleep disorders</topic><topic>depression</topic><topic>Sleep Disorders Questionnaire (SDQ)</topic><topic>Zung Depression Scale (ZDS)</topic></subject><relatedItem type="host"><titleInfo><title>Acta Neurologica Scandinavica</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0001-6314</identifier><identifier type="eISSN">1600-0404</identifier><identifier type="DOI">10.1111/(ISSN)1600-0404</identifier><identifier type="PublisherID">ANE</identifier><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>104</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>275</start><end>280</end><total>6</total></extent></part></relatedItem><identifier type="istex">8E634EA3AD763BFABCC9082980339A44820FE673</identifier><identifier type="DOI">10.1034/j.1600-0404.2001.00024.x</identifier><identifier type="ArticleID">ANE024</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Munksgaard International Publishers</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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